2006-present     [back to top]

Zhao P, Waxman SG, Hains BC.
Modulation of thalamic nociceptive processing after SCI through remote activation of thalamic microglia by cysteine-cysteine chemokine ligand 21 (CCL21).
J. Neurosci. 27:8893-8902, 2007.

Zhao P, Waxman SG, Hains BC.
ERK-regulated microglia-neuron signaling by PGE2 underlies pain following spinal cord injury.
J. Neurosci. 27:2357-2368, 2007.

Hains BC, Waxman SG.
Sodium channel expression and the molecular pathophysiology of pain after SCI..
Prog. Brain Res. 161:195-203, 2007.

Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, Sartorelli AC.
Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response.
Mol. Pharmacol. 73:243-251, 2007.

Hains BC, Waxman SG.
Activated microglia contribute to the maintenance of chronic pain following spinal cord injury.
J. Neurosci. 26:4308-4317, 2006.

Woolfe F, Waxman SG, Hains BC.
In silico modeling of the achievability of axonal reconnection within a discrete fiber tract transected after spinal cord injury.
J. Neurotrauma 24:421-432, 2006.

Zhao P, Waxman SG, Hains BC.
Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury.
Molecular Pain 2:27-37, 2006.

Lampert A, Hains BC, Waxman SG.
Dorsal horn neurons express ramp currents, and accelerated repriming associated with Nav1.3 upregulation after spinal cord injury.
Exp. Brain Res. 174:660-666, 2006.

Black JA, Lu S, Hains BC, Waxman SG.
Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE.
Brain 129:3196-3208, 2006.

Waxman SG, Hains BC.
Fire and Phantoms after Spinal Cord Injury: Sodium Channels and Central Pain.
Trends in Neurosciences 29:207-215, 2006.

Hains BC, Saab CY, Waxman SG.
Alterations in thalamic burst firing properties after spinal cord injury.
J. Neurophys. 95:3343-3352, 2006.

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2000-2005    [back to top]

Sasaki M*, Hains BC*, Lankford KL, Waxman SG, Kocsis, JD.
Protection of corticospinal tract neurons following dorsal spinal cord transection and engraftment of olfactory ensheathing cells.
Glia 53:352-359, 2005. *Contributed equally to this article.

Hains BC, Waxman SG.
Neuroprotection by sodium channel blockade with phenytoin in an experimental model of glaucoma.
Invest. Ophthalmol. Vis. Sci. 46:4164-41969, 2005.

Hains BC, Saab CY, Waxman SG.
Changes in electrophysiological properties and sodium channel Nav1.3 expression in the thalamic amplifier after spinal cord injury.
Brain 128:2359-2371, 2005.

Craner MJ, Damarjian TG, Liu S, Hains BC, Lo AC, Black JA, Newcombe J, Cuzner ML, Waxman SG.
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.
Glia 49:220-229, 2005.

Klein JP, Hains BC, Craner MJ, Black JA, Waxman SG.
Apoptosis in vaspressinergic hypothalamic neurons in chronic diabetes mellitus.
Neurobiol. Disease 15:221-228, 2004.

Hains BC.
Bradykinin receptor antagonism is poised to slow pain development.
Drug Discovery Today, 2004.

Gwak YS, Hains BC, Hulsebosch CE.
Locomotor Recovery and Mechanical Hyperalgesia Following Spinal Cord Injury Depends on Age at Time of Injury in Rat.
Neurosci. Lett. 362:232-235, 2004.

Hains BC, Saab CY, Lo AC, Black JA, Waxman SG.
Sodium channel blockade with phenytoin promotes neuroprotection and enhancement of functional motor recovery after contusion SCI.
Exp. Neurol. 188:365-77, 2004.

Hains BC.
The painful truth: the P2X class of ATP receptors.
Drug Discovery Today 9:93-94, 2004.

Hains BC, Saab CY, Klein JP, Craner MJ, Waxman SG.
Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.
J. Neurosci. 24:4832-4839, 2004.

Gwak YS, Hains, BC, Johnson KM, Hulsebosch CE.
Effect of age at time os spinal cord injury on behavioral outcomes in rat.
J. Neurotrauma. 21:983-988, 2004.

Hains BC.
Un-seizing the gain in pain with novel antiepileptic agents.
BioMedNet Research Update/Drug Discovery Today 9:93-94, 2004.

Hains BC, Willis WD, Hulsebosch CE.
Serotonin receptors 5-HT1A and 5-HT3 reduce hyperexcitability of dorsal horn neurons after chronic spinal cord hemisection injury in rat.
Exp. Brain Res. 149: 174-186, 2003.

Hains BC, Eaton MJ, Willis WD, Hulsebosch CE.
Serotonergic neural precursor cell grafts attenuate bilateral hyperexcitability of dorsal horn neurons after spinal hemisection in rat.
Neuroscience 116:1097-1110, 2003.

Hains BC, Willis WD, Hulsebosch CE.
Temporal plasticity of dorsal horn somatosensory neurons after acute and chronic spinal cord hemisection in rat.
Brain Res. 970:238-241, 2003.

Hains BC, Black JA, Waxman SG.
Primary motor neurons undergo apoptosis after axotomizing spinal cord injury.
J. Comp. Neurol. 462 328-341, 2003.

Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG.
Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury.
J. Neurosci. 23:8881-8892, 2003.

Craner MJ, Hains BC, Klein JP, Black JA, Waxman SG.
Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.
Brain 127:294-303, 2003.

Hains BC, Hulsebosch CE, Willis WD.
Differential effects of BDNF on spinal dorsal horn neurons after spinal cord hemisection injury.
Neurosci. Lett. 320:125-128, 2002.

Hains BC, Yucra JA, Hulsebosch CE.
Intralesion transplantation of serotonergic precursors enhances locomotor recovery but has no effect on development of chronic central pain following hemisection injury.
Neurosci. Lett. 324:222-226, 2002.

Hains BC, Everhart AW, Hulsebosch CE.
Changes in serotonin, serotonin transporter expression, and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in rat.
Exp. Neurol. 175:347-362, 2002.

Hains BC, Black JA, Waxman SG.
Primary motor neurons fail to up-regulate voltage-gated sodium channel Nav1.3/Brain type III following axotomy resulting from spinal cord injury.
J. Neurosci. Res. 70 546-552, 2002.

Hains BC, Yucra JA, Hulsebosch CE.
Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective COX-2 inhibitor NS-398.
J. Neurotrauma 18: 409-423, 2001.

Mills CD, Hains BC, Johnson KM, Hulsebosch CE.
Strain and model differences in behavioral outcomes after spinal cord injury in rat.
J. Neurotrauma 18:743-756, 2001.

Hains BC, Fullwood SD, Eaton MJ, Hulsebosch CE.
Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates serotonin transporter, and increases BDNF tissue content in rat.
Brain Res. 913:35-46, 2001.

Hains BC, Johnson KM, Eaton MJ, Hulsebosch CE.
Engraftment of serotonergic precursors enhances locomotor function and attenuates chronic central pain behavior following spinal hemisection injury in the rat.
Exp. Neurol. 171:361-378, 2001.

Hains BC, Chastain KM, Everhart AW, McAdoo DJ, Hulsebosch CE.
Transplants of adrenal medullary chromaffin cells reduce mechanical and thermal allodynia in a model of chronic central pain after spinal cord injury.
Exp. Neurol. 164:426-437, 2000.

Hulsebosch CE, Hains BC, Waldrep K., Young W.
Bridging the gap: From discovery to clinical trails in spinal cord injury.
J. Neurotrauma 17:1117-1128, 2000.

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